FOXP3 and the regulation of Treg/Th17 differentiation
Abstract
CD4 T cell lineages are marked by the signature transcription factor each lineage expresses. For example, regulatory T cells (Tregs) are characterized by expression of FOXP3, which is either induced during thymic development for natural Tregs (nTregs), or in the periphery in the presence of TGF-beta and retinoic acid for induced Tregs (iTreg). Interestingly, recent work has shown that the signature transcription factor for Th17 cells, RORgammat, is also induced by TGF-beta, thus linking the differentiation of the Treg and Th17 lineages. In the absence of a second signal from a proinflammatory cytokine, FOXP3 can inhibit RORgammat function and drive Treg differentiation. However, when the cell also receives a signal from a proinflammation cytokine (e.g., IL-6), FOXP3 function is inhibited and the Th17 differentiation pathway is induced. Therefore, it is the balance between FOXP3 and RORgammat function that determines CD4 T cell fate and the type of immune response that will be generated.
Key Biomarkers
Cited By (3)
- Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by Il-4 and STAT6Journal of Leukocyte Biology · 2010
- Nature and nurture in Foxp3 (+) regulatory T cell development, stability, and functionHuman Immunology · 2012
- Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspectiveNature reviews. Immunology · 2009
References (5)
- Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3The Journal of Experimental Medicine · 2003
- A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responsesNature Immunology · 2008
- A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral BloodThe Journal of Immunology · 2001
Related Papers
- Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177Frontiers in Immunology · 2022 · 1 shared tag
- Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adipose Tissue of MiceInternational Journal of Molecular Sciences · 2024 · 1 shared tag
- Fungal immunity and pathogenesis in mammals versus the invertebrate model organismGalleria mellonellaPathogens and Disease · 2021 · 1 shared tag
- TLR signaling pathway and the effects of main immune cells and epigenetics factors on the diagnosis and treatment of infertility and sterilityHeliyon · 2024 · 1 shared tag
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 1 shared tag
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 1 shared tag