Role of Akt signaling in vascular homeostasis and angiogenesis
Shiojima I, Walsh K2002Circulation ResearchReview
Cardiovascular
Abstract
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic activity of Akt is well known, it also regulates other aspects of cellular functions, including migration, glucose metabolism, and protein synthesis. In this review, Akt signaling in endothelial cells and its critical roles in the regulation of vascular homeostasis and angiogenesis will be discussed.
Key Biomarkers
Akt signalingphosphatidylinositol-3 kinaseTGF-beta
Cited By (3)
- Losartan Metabolite EXP3179 Activates Akt and Endothelial Nitric Oxide Synthase via Vascular Endothelial Growth Factor Receptor-2 in Endothelial CellsCirculation · 2005
- Beneficial effect of insulin in hyperhomocysteinemia and diabetes mellitus-induced vascular endothelium dysfunction: role of phosphoinositide dependent kinase and protein kinase BMolecular and Cellular Biochemistry · 2011
- Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptinRegulatory Peptides · 2007
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