The role of erythropoietin in myocardial protection: potential mechanisms and applications
Abstract
The glycoprotein erythropoietin was originally discovered as a principal regulator that promotes the survival, proliferation and differentiation of erythroid progenitor cells. Despite potentially detrimental effects, such as increased blood pressure and hyperviscosity, recombinant human erythropoietin has been demonstrated to be a safe drug, as millions of anemia sufferers have received it over the last decade as a form of treatment. Recently, erythropoietin receptors have been discovered in a variety of tissues, including the cardiovascular system, and erythropoietin has been demonstrated to have a beneficial effect in congestive heart failure patients with anemia. The purpose of this review is to summarize the pleiotropic cardioprotective effects of erythropoietin in the cardiovascular system and to evaluate its potential role as a biomarker in these disorders.
Key Biomarkers
Symptom Clusters
References (7)
- Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failureCirculation · 2003
- Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathwayBiochemical and Biophysical Research Communications · 2003
- Hematopoietic factor erythropoietin fosters neuroprotection through novel signal; transduction cascadesJournal of Cerebral Blood Flow & Metabolism · 2002
- Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic RetinopathyNew England Journal of Medicine · 2005
- New avenues of exploration for erythropoietinJAMA · 2005
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