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Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes

Genc K, Genc S, Baskin H +1 more2006Physiological ResearchJournal Article
10.33549/physiolres.930749PubMedFree full text
Neurological

Abstract

In the present study, we investigated whether erythropoietin (Epo) has a protective effect against cytotoxicity induced by interferon-gamma (IFN-gamma ) and lipopolysaccharide (LPS) in primary rat oligodendrocyte cultures. The possible modulatory effect of erythropoietin on inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production were also analyzed. Erythropoietin exerted a significant protective effect against IFN-gamma and LPS-induced oligodendrocyte injury as determined by lactate dehydrogenase assay. Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. These results suggest that erythropoietin has protective effects against inflammatory oligodendrocyte injury in vitro and may play a protective role in neurological disorders characterized by oligodendrocyte death, such as multiple sclerosis.

Key Biomarkers

inducible nitric oxide synthase (iNOS) mRNALactate dehydrogenaseNitrite production

Cited By (1)

  • Erythropoietin Is Neuroprotective in a Preterm Ovine Model of Endotoxin-Induced Brain InjuryJournal of Neuropathology & Experimental Neurology · 2010

References (4)

  • Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascadesNature · 2001
  • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injuryProceedings of the National Academy of Sciences · 2000
  • Erythropoietin and the nervous systemBrain Research · 2004
  • Erythropoietin in the brain: can the promise to protect be fulfilled?Trends in Pharmacological Sciences · 2004

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