β‐glucan recognition by the innate immune system
Abstract
Beta-glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing beta-glucan in its various forms. This review explores what is currently known about beta-glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin-1, as we know the most about how this key beta-glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.
Part of Mold & water-damaged buildings research · Curated by Lauren Lowenstein, The Biotoxin Lady
Cited By (5)
- Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferationCellular Immunology · 2011
- Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistanceFrontiers in Immunology · 2022
- An Alpha-Glucan from Lomentospora prolificans Mediates Fungal–Host Interaction Signaling through Dectin-1 and MincleJournal of Fungi · 2023
- Persisting Cryptococcus yeast species Vishniacozyma victoriae and Cryptococcus neoformans elicit unique airway inflammation in mice following repeated exposureFrontiers in Cellular and Infection Microbiology · 2023
- Ex Vivo Cytokine Release and Pattern Recognition Receptor Expression of Subjects Exposed to Dampness: Pilot Study to Assess the Outcome of Mould Exposure to the Innate Immune SystemPLoS ONE · 2013
References (2)
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