Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation
Katharina Heß, Ramzi Ajjan, Fladia Phoenix +3 more2012PLoS ONEJournal Article
Hematological
Abstract
We show that MASP-1 interacts with plasma clot formation on different levels and influences fibrin structure. Although MASP-1-induced fibrin formation is thrombin-dependent, MASP-1 directly activates prothrombin, FXIII and TAFI. We suggest that MASP-1, in concerted action with other complement and coagulation proteins, may play a role in fibrin clot formation.
Key Biomarkers
D-dimerFibrinFXIIIMASP-1prothrombinTAFI
References (4)
- Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clotImmunology · 2010
- Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathwayInternational Immunology · 2007
- Serine proteases of the classical and lectin pathways: similarities and differencesImmunobiology · 2007
- The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogenBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2008
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