Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation

Abstract

We show that MASP-1 interacts with plasma clot formation on different levels and influences fibrin structure. Although MASP-1-induced fibrin formation is thrombin-dependent, MASP-1 directly activates prothrombin, FXIII and TAFI. We suggest that MASP-1, in concerted action with other complement and coagulation proteins, may play a role in fibrin clot formation.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

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