Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus

Kim J; Ryu H; Choi S; Kang T

doi:10.1186/1742-2094-9-6

Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus

Kim J, Ryu H, Choi S +1 more2012Journal of NeuroinflammationJournal Article

10.1186/1742-2094-9-6 PubMed Free full text

CardiovascularImmune/InnateNeurological

Abstract

Status epilepticus (SE) induces severe vasogenic edema in the piriform cortex (PC) accompanied by neuronal and astroglial damages. To elucidate the mechanism of SE-induced vasogenic edema, we investigated the roles of tumor necrosis factor (TNF)-a in blood-brain barrier (BBB) disruption during vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced SE.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

Neutrophil infiltrationp65 NF-kB phosphorylation (Thr435)SMI-71 expressionTNF-αVasogenic edema

Symptom Clusters

Astroglial damageBlood-brain barrier disruptionNeuroinflammationNeuronal damageVasogenic edema