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Mechanisms of hair cell death and protection

Cheng A, Cunningham L, Rubel E2005Current Opinion in Otolaryngology & Head & Neck SurgeryReview
10.1097/01.moo.0000186799.45377.63PubMed
Neurological

Abstract

The mechanisms of sensory hair cell degeneration in response to different ototoxic stimuli share a final common pathway: caspase activation. Inhibition of caspases prevents or delays hair cell death and may preserve hearing/balance function. Inhibition of mitogen-activated protein kinases protects against noise-induced and aminoglycoside-induced but not cisplatin-induced hair cell death, which suggests divergent upstream regulatory mechanisms.

Key Biomarkers

Caspase activationMitogen-activated protein kinases

Symptom Clusters

Balance dysfunctionHearing loss

Cited By (1)

  • The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotective strategiesRecent Patents on CNS Drug Discovery · 2010

References (1)

  • A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing lossJournal of Neuroscience · 2003

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