Mechanisms of hair cell death and protection
Cheng A, Cunningham L, Rubel E2005Current Opinion in Otolaryngology & Head & Neck SurgeryReview
Auditory/VestibularNeurological
Abstract
The mechanisms of sensory hair cell degeneration in response to different ototoxic stimuli share a final common pathway: caspase activation. Inhibition of caspases prevents or delays hair cell death and may preserve hearing/balance function. Inhibition of mitogen-activated protein kinases protects against noise-induced and aminoglycoside-induced but not cisplatin-induced hair cell death, which suggests divergent upstream regulatory mechanisms.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Caspase activationMitogen-activated protein kinases
Symptom Clusters
Balance dysfunctionHearing loss
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