Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms
Michaël Maes2008Current Opinion in PsychiatryReview
GastrointestinalImmune/InnateNeurological
Abstract
'Functional' symptoms, as occurring in CFS and somatization, have a genuine organic cause, that is activation of peripheral and central IO&NS pathways and gut-derived inflammation. The development of new drugs, aimed at treating those disorders, should target these IO&NS pathways.
Key Biomarkers
Inflammatory markersNitrosative stress markersOxidative stress markers
Symptom Clusters
Chronic fatiguePsychosomatic symptomsSomatization
References (2)
- Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationGlia · 2007
- Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeabilityJournal of Affective Disorders · 2007
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