Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms

Michaël Maes

doi:10.1097/yco.0b013e32831a4728

Inflammatory and oxidative and nitrosative stress pathways underpinning chronic fatigue, somatization and psychosomatic symptoms

Michaël Maes2008Current Opinion in PsychiatryReview

10.1097/yco.0b013e32831a4728 PubMed

GastrointestinalImmune/InnateNeurological

Abstract

'Functional' symptoms, as occurring in CFS and somatization, have a genuine organic cause, that is activation of peripheral and central IO&NS pathways and gut-derived inflammation. The development of new drugs, aimed at treating those disorders, should target these IO&NS pathways.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

Inflammatory markersNitrosative stress markersOxidative stress markers

Symptom Clusters

Chronic fatiguePsychosomatic symptomsSomatization

Cited By (1)

Insights into the Complex Biological Network Underlying Myalgic Encephalomyelitis/Chronic Fatigue SyndromeInternational Journal of Molecular Sciences · 2025

References (2)

Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationGlia · 2007
Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeabilityJournal of Affective Disorders · 2007