HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
Lucy R. Wedderburn, N. McHugh, Hector Chinoy +8 more2007Lara D. VeekenJournal Article
DermatologicalImmune/InnateMusculoskeletal
Abstract
We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM.
Key Biomarkers
AutoantibodiesHLA class II haplotypes
Symptom Clusters
Juvenile dermatomyositisJuvenile dermatomyositis-scleroderma overlap
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