Association of HLA‐DQA1∗03011‐DQB1∗0301 haplotype with the development of respiratory scleroma

Sanchez-Marin L; Bross-Soriano D; Arrieta J; Kawa-Karasik S; Martinez-Vilchis V; Jimenez-Lucio R; Olivo-Diaz A

doi:10.1016/j.otohns.2006.08.032

Association of HLA‐DQA1∗03011‐DQB1∗0301 haplotype with the development of respiratory scleroma

Sanchez-Marin L, Bross-Soriano D, Arrieta J +4 more2007OtolaryngologyJournal Article

10.1016/j.otohns.2006.08.032 PubMed

Abstract

ObjectiveRespiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA‐DQ3. In this study, molecular association of HLA class II and RS was determined.Study Design and SettingNine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.ResultsStatistical analysis demonstrated association between DQB1*0301 and susceptibility to RS (Pc = 0.004). Haplo‐type analysis showed an association of DQA1*03011‐DQB1*0301 (P = 1.21E‐19) and DRB1*0407‐DQA1*03011‐DQB1*0301 (P = 0.0002).ConclusionsResults established that DQA1*03011‐DQB1*0301 haplotype is a strong risk factor for development of RS.© 2007 American Academy of Otolaryngology–Head and Neck Surgery Foundation. All rights reserved.

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