The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients

Ward NS; Casserly B; Ayala A

doi:10.1016/j.ccm.2008.06.010

The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients

Ward NS, Casserly B, Ayala A2008Clinics in Chest MedicineReview

10.1016/j.ccm.2008.06.010 PubMed Free full text

Immune/Innate

Abstract

Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

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