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Premorbid predictors of chronic fatigue

Kenji Kato, Patrick F. Sullivan, Birgitta Evengård +1 more2006Archives of General PsychiatryJournal Article
10.1001/archpsyc.63.11.1267PubMed
Neurological

Abstract

Elevated premorbid stress is a significant risk factor for chronic fatigue-like illness, the effect of which may be buffered by genetic influences. Emotional instability assessed 25 years earlier is associated with chronic fatigue through genetic mechanisms contributing to both personality style and expression of the disorder. These findings suggest plausible mechanisms for chronic fatiguing illness.

Cited By (2)

  • Association of peripheral inflammatory markers with chronic fatigue in a population-based sampleBrain Behavior and Immunity · 2009
  • Does hypothalamic-pituitary- adrenal axis hypofunction in chronic fatigue syndrome reflect a ‘crash’ in the stress system? Med HypothesesMedical Hypotheses · 2009

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