Cell-surface IL-7 receptor expression facilitates the purification of FOXP3 (+) regulatory T cells

Banham AH2006Trends in ImmunologyReview

10.1016/j.it.2006.10.002 PubMed

Immune/Innate

Abstract

FOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and modulating adaptive immune responses. Functional studies of Treg cells have been hampered by a lack of suitable cell-surface markers that specifically enable their purification without contamination by non-regulatory CD25+ effector T cells. Two recent studies have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells from activated T cells, facilitating both Treg-cell purification and their functional characterization in human diseases. CD127 uniquely enables the purification of FOXP3+ Treg cells and, potentially, also "adaptive" regulatory T-cell subsets from the CD4+CD25- T-cell population.

Key Biomarkers

CD127CD25Foxp3IL-7 receptor

Cited By (4)

Low responder T cell susceptibility to the suppressive function of regulatory T cells in patients with dilated cardiomyopathyHeart · 2010
The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitroInternational Immunology · 2007
Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3) (+) T cells into CD127(-) CD25(high) FoxP3 (+) regulatory T cellsClinical & Experimental Immunology · 2011
Flow Cytometry Developments and Perspectives in Clinical Studies: Examples in ICU PatientsMethods in molecular biology · 2011