The regulation of Foxp3 expression in regulatory CD4+CD25+T cells: Multiple pathways on the road
Abstract
AbstractRegulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the development and function of CD4+CD25+Treg cells. Though it is well defined that Foxp3 expression is sufficient to program CD4+CD25+Treg cell development, the physiological factors initiating intracellular Foxp3 expression remain poorly understood so far. In the present manuscript, we try to summarize the recent advances regarding the regulatory roles of T‐cell receptor (TCR), co‐stimulatory molecules, interleukin‐2 (IL‐2), transforming growth factor‐β (TGF‐β) and beyond pathways on Foxp3 expression. J. Cell. Physiol. 211: 590–597, 2007. © 2007 Wiley‐Liss, Inc.
Key Biomarkers
Symptom Clusters
Cited By (3)
- Decreased FOXP3 expression in small airways of smokers with COPDEuropean Respiratory Journal · 2009
- Plasmodium falciparum–Mediated Induction of Human CD25hiFoxp3hi CD4 T Cells Is Independent of Direct TCR Stimulation and Requires IL-2, IL-10 and TGFβPLoS Pathogens · 2009
- The significantly enhanced frequency of functional CD4+CD25+FoxP3+ T regulatory cells in therapeutic dose aspirin-treated miceTransplant Immunology · 2009
References (5)
- Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3The Journal of Experimental Medicine · 2003
- A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral BloodThe Journal of Immunology · 2001
- TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory CellsThe Journal of Immunology · 2006
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