Longitudinal analysis of regional grey matter loss in Huntington disease: effects of the length of the expanded CAG repeat
Heloísa Helena Ruocco, Leonardo Bonilha, Li M. Li +2 more2007Journal of Neurology Neurosurgery & PsychiatryJournal Article
Neurological
Abstract
These results confirm that brain atrophy progresses after the clinical onset of HD and that regional atrophy is related to symptom severity. Moreover, our results also indicate that intensity and rate of progression of brain atrophy are more pronounced in patients with larger, expanded CAG repeat sequences.
Key Biomarkers
Brain atrophyCAG repeat lengthCaudate atrophyRegional grey matter loss
Symptom Clusters
CNS illnessProgressive neurodegeneration
Related Papers
- Association of mold exposure and solid household fuel use with depression and anxiety among older adults in ChinaEnvironmental Health · 2025 · 1 shared tag
- Pain, Fear, Anxiety, and Stress: Relations to the Endogenous Opioid SystemAdvances in neurobiology · 2024 · 1 shared tag
- Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular ModelsFrontiers in Neuroscience · 2021 · 1 shared tag
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 1 shared tag
- High Value Phycotoxins From the Dinoflagellate ProrocentrumFrontiers in Marine Science · 2021 · 1 shared tag
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 1 shared tag