Longitudinal analysis of regional grey matter loss in Huntington disease: effects of the length of the expanded CAG repeat
Heloísa Helena Ruocco, Leonardo Bonilha, Li M. Li +2 more2007Journal of Neurology Neurosurgery & PsychiatryJournal Article
Neurological
Abstract
These results confirm that brain atrophy progresses after the clinical onset of HD and that regional atrophy is related to symptom severity. Moreover, our results also indicate that intensity and rate of progression of brain atrophy are more pronounced in patients with larger, expanded CAG repeat sequences.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Brain atrophyCAG repeat lengthCaudate atrophyRegional grey matter loss
Symptom Clusters
CNS illnessProgressive neurodegeneration
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