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Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis

Salem Hannoun, Françoise Durand‐Dubief, Christian Confavreux +5 more2012American Journal of NeuroradiologyJournal Article
10.3174/ajnr.a2983PubMedFree full text
Neurological

Abstract

Increased FA in the caudate and the thalamus may constitute a sensitive marker of MS pathologic processes, such as loss of dendrites and/or swelling of neuronal cell bodies.

Key Biomarkers

Caudate atrophyDiffusion Tensor Imaging (DTI)Fractional Anisotropy (FA)Thalamic changes

References (1)

  • Caudate nuclei volume, diffusion tensor metrics, and T2 relaxation in healthy adults and relapsing‐remitting multiple sclerosis patients: Implications for understanding gray matter degenerationJournal of Magnetic Resonance Imaging · 2009

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