'Unicorn' among rats exposed to mycotoxins from Fusarium
1983Toxicology Letters
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryImmune/InnateNeurologicalRespiratory/Sinus
Indoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsWater-Damaged Buildings (WDB)
Abstract
A horn-like nodule developed in the middle of the forehead of a white rat, exposed perinatally to T-2 toxin and to zearalenone, the secondary metabolites of Fusarium. The hard nodule consisted mainly of keratine, derived from a squamous carcinoma spreading through the nasal turbinals and invading the brain.
Key Biomarkers
Abnormal QEEG findingsAbnormal T and B cell subsetsAntinuclear autoantibodies (ANA)Autoantibodies against CNS and PNS myelinAutoantibodies against smooth muscle (ASM)Elevated neural autoantibodies (anti-myelin basic protein, anti-ganglioside GM1, anti-myelin-associated glycoprotein)Trichothecene toxins in urine and serum
Symptom Clusters
Autonomic nervous system dysfunctionBalance and coordination impairmentCognitive dysfunction and encephalopathyDepression and mood disordersNeuropsychological impairment (memory, concentration, visuospatial learning, psychomotor speed)Peripheral neuropathy (numbness, tingling, tremors, muscle weakness)Respiratory symptoms (rhinorrhea, wheezing, airway obstruction)Sinus symptoms (sinus tenderness)
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