'Unicorn' among rats exposed to mycotoxins from Fusarium
R Schoental1983Toxicology LettersJournal Article
Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryImmune/InnateNeurologicalRespiratory/Sinus
Abstract
A horn-like nodule developed in the middle of the forehead of a white rat, exposed perinatally to T-2 toxin and to zearalenone, the secondary metabolites of Fusarium. The hard nodule consisted mainly of keratine, derived from a squamous carcinoma spreading through the nasal turbinals and invading the brain.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Abnormal QEEG findingsAbnormal T and B cell subsetsAntinuclear autoantibodies (ANA)Autoantibodies against CNS and PNS myelinAutoantibodies against smooth muscle (ASM)Elevated neural autoantibodies (anti-myelin basic protein, anti-ganglioside GM1, anti-myelin-associated glycoprotein)Trichothecene toxins in urine and serum