Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils
Tsuchihashi Y, Oishi K, Yoshimine H +6 more2002Antimicrobial Agents and ChemotherapyJournal Article
Immune/InnateRespiratory/Sinus
Abstract
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
Interleukin-8 (IL-8)Lipopolysaccharide (LPS)
Symptom Clusters
Chronic airway diseases
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