Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics

Yao Y; Sturdevant DE; Villaruz; Xu L; Gao Q; Otto M

doi:10.1128/iai.73.3.1856-1860.2005

Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics

Yao Y, Sturdevant DE, Villaruz +3 more2005Infection and ImmunityJournal Article

10.1128/iai.73.3.1856-1860.2005 PubMed Free full text

Abstract

Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis , and potential targets for drug development against S. epidermidis infections.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

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The Bacterial Insertion Sequence Element IS 256 Occurs Preferentially in Nosocomial Staphylococcus epidermidis Isolates: Association with Biofilm Formation and Resistance to AminoglycosidesInfection and Immunity · 2004