Reduced Triclosan Susceptibility in Methicillin-Resistant Staphylococcus epidermidis
Schmid MB, Kaplan N2004Antimicrobial Agents and ChemotherapyJournal Article
Abstract
Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates ( n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC 50 ) of 0.12 μg/ml and a MIC 90 of 0.25 μg/ml. Staphylococcus epidermidis isolates ( n = 96) were less susceptible, with a MIC 50 of 0.12 μg/ml and a MIC 90 of 8 μg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.
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