The Recombinant Phage Lysin LysK Has a Broad Spectrum of Lytic Activity against Clinically Relevant Staphylococci, Including Methicillin-Resistant Staphylococcus aureus
O'Flaherty S, Coffey A, Meaney W +2 more2005Journal of BacteriologyJournal Article
Abstract
This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis . Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus . LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.
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