Transmission Electron Microscopic Study of Antibiotic Action on Klebsiella pneumoniae Biofilm
Zahller J, Stewart PS2002Antimicrobial Agents and ChemotherapyJournal Article
Abstract
The penetration of ampicillin and ciprofloxacin through biofilms formed by Klebsiella pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived antibiotic treatment, some protective mechanism other than inadequate penetration must have been at work in the biofilm.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Cited By (3)
- Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and TobramycinAntimicrobial Agents and Chemotherapy · 2003
- Role of Nutrient Limitation and Stationary-Phase Existence in Klebsiella pneumoniae Biofilm Resistance to Ampicillin and CiprofloxacinAntimicrobial Agents and Chemotherapy · 2003
- Secretion of Proteases by Pseudomonas aeruginosa Biofilms Exposed to CiprofloxacinAntimicrobial Agents and Chemotherapy · 2005