Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides

Pruner AL; Malbruny B; Tande D; Picard B; Leclarcq R

doi:10.1128/aac.46.9.3054-3056.2002

Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides

Pruner AL, Malbruny B, Tande D +2 more2002Antimicrobial Agents and ChemotherapyJournal Article

10.1128/aac.46.9.3054-3056.2002 PubMed Free full text

Abstract

Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr (A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.

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