Antibodies to myelin basic protein in children with autistic behavior
Abstract
Based on a possible pathological relationship of autoimmunity to autism, antibodies reactive with myelin basic protein (anti-MBP) were investigated in the sera of autistic children. Using a screening serum dilution of 1:400 in the protein-immunoblotting technique, approximately 58% (19 of 33) sera of autistic children (< or = 10 years of age) were found to be positive for anti-MBP. This result in autistics was significantly (p < or = .0001) different from the controls (8 of 88 or only 9% positive), which included age-matched children with normal health, idiopathic mental retardation (MR) and Down syndrome (DS), and normal adults of 20 to 40 years of age. Since autism is a syndrome of unknown etiology, it is possible that anti-MBP antibodies are associated with the development of autistic behavior.
Key Biomarkers
Symptom Clusters
Cited By (9)
- Short-term benefit from oral vancomycin treatment of regressive-onset autismJournal of Child Neurology · 2000
- Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsyBiological Psychiatry · 2006
- Immunological findings in autismInternational review of neurobiology · 2005
- Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000PEDIATRICS · 2000
- Serum autoantibodies to brain in Landau-Kleffner Variant, autism, and other neurologic disordersThe Journal of Pediatrics · 1999
- Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regressionJournal of Neuroimmunology · 2001
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