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IL-1 signaling in atherosclerosis: sibling rivalry

Sheedy FJ, Moore KJ2013Nature ImmunologyNarrative Review
CardiovascularImmune/Innate

Abstract

Signaling via the interleukin-1 (IL-1) family, particularly by IL-1β has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1α to promote vascular inflammation identify a key role for this less-well-studied cytokine.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

IL-1α (Interleukin-1 alpha)IL-1β (Interleukin-1 beta)