Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group
Rajendra A. Morey, Andrea L. Gold, Kevin S. LaBar +7 more2012Archives of General PsychiatryJournal Article
Neurological
Abstract
These results provide clear evidence of an association between a smaller amygdala volume and PTSD. The lack of correlation between trauma load or illness chronicity and amygdala volume suggests that a smaller amygdala represents a vulnerability to developing PTSD or the lack of a dose-response relationship with amygdala volume. Our results may trigger a renewed impetus for investigating structural differences in the amygdala, its genetic determinants, its environmental modulators, and the possibility that it reflects an intrinsic vulnerability to PTSD.
Key Biomarkers
Amygdala volume
Symptom Clusters
PTSD
References (2)
- Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysisProgress in Neuro-Psychopharmacology and Biological Psychiatry · 2010
- Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorderBiological Psychiatry · 2004
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