Cytokines in Epithelial-Mesenchymal Transition: A New Insight Into Obstructive Nephropathy
Ahmad BaniHani, Matthew T. Campbell, Daniel R. Meldrum +1 more2008The Journal of UrologyReview
Renal
Abstract
Epithelial-mesenchymal transition is a cellular mechanism that has long been recognized as a central feature of normal development. However, increasing evidence implicates epithelial-mesenchymal transition in the pathophysiology of tubulointerstitial fibrosis and chronic renal disease. Recent insights into the molecular events and intrinsic signaling pathways that are active during epithelial-mesenchymal transition have evoked novel therapeutic strategies aimed at halting the onset and progression of chronic renal fibrosis.
Part of CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
CytokinesTGF-β1
Symptom Clusters
Chronic renal diseaseTubulointerstitial fibrosis
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