Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System
Jing Ren, Yuanyuan Xiao, Di Wang +13 more2024Dose-ResponseJournal Article
Ocular
Abstract
Our study found PRCP dose was decreased in POAG patients' aqueous humor, and it might cause high level of AngII. Restoration of PRCP rescued fibrosis of TM cells and ameliorated IOP in AngII treatment mouse.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Related Papers
- Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventionsCell Death Discovery · 2024 · 1 shared tag
- Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological MechanismsClinical Reviews in Allergy & Immunology · 2025 · 1 shared tag
- A Narrative Review of the Immunomodulatory Effects of Acthar® Gel Beyond Its Steroidogenic PropertiesAdvances in Therapy · 2025 · 1 shared tag
- Immunomodulatory Role of Neuropeptides in the CorneaBiomedicines · 2022 · 1 shared tag
- Novel Method for Assessing the Protection Lifetime of Building Coatings against FungiCoatings · 2023 · 1 shared tag
- In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformaticsJournal of Leukocyte Biology · 2022 · 1 shared tag