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A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans

John H. Dodd, Robert Jordan, Marie Makhlina +6 more2023Frontiers in ImmunologyJournal Article
10.3389/fimmu.2023.1083333PubMedFree full text
GastrointestinalImmune/Innate

Abstract

Collectively, these findings support further research into the oral formulation of PL8177 as a possible therapeutic for GI inflammatory diseases in humans.

Cited By (4)

  • The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic PotentialsCells · 2023
  • Relevance and consequence of chronic inflammation for obesity developmentMolecular and Cellular Pediatrics · 2023
  • Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and DiseasesDiseases · 2025
  • Resolution Pharmacology: State-of-the-art and therapeutic landscapePharmacological Reviews · 2025

References (7)

  • α-Melanocyte-Stimulating Hormone Inhibits Allergic Airway InflammationThe Journal of Immunology · 2003
  • α-Melanocyte-stimulating Hormone Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Production in Leukocytes by Modulating Protein Kinase A, p38 Kinase, and Nuclear Factor κB Signaling PathwaysJournal of Biological Chemistry · 2003

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