Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice
Mohammad Badr, Rhonda L. McFleder, Jingjing Wu +7 more2022Journal of NeuroinflammationJournal Article
Immune/InnateNeurological
Abstract
Our data indicate that immune modulation by Treg expansion at a timepoint of overt inflammation is effective for treatment of hαSyn Parkinson's disease mice and suggest that the concept of early immune therapy could pose a disease-modifying option for Parkinson's disease patients.
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