Non-Canonical Effects of ACTH: Insights Into Adrenal Insufficiency

Valeria Hasenmajer, Ilaria Bonaventura, Marianna Minnetti +3 more2021Frontiers in EndocrinologyReview

10.3389/fendo.2021.701263 PubMed Free full text

Endocrine (ADH/ACTH/MSH)Hypothalamic-PituitaryOcular

Abstract

The role of ACTH in maintaining the function of the hypothalamic-pituitary-adrenal axis is well known. Conversely, if we broaden our vision and analyze its role as a potential treatment strategy in other conditions, it will be evident in the literature that researchers seem to have abandoned this aspect in studies conducted several years ago. We believe it is worth re-evaluating the role of ACTH considering its noncanonical effects on the adrenal gland itself and on extra-adrenal organs and tissues; however, this would not have been possible without the recent advances in the pertinent technologies.

Key Biomarkers

ACTH

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