Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries
Gal Reches, N. Blondheim-Shraga, Florent Carrette +8 more2022Inflammation and RegenerationJournal Article
GastrointestinalImmune/Innate
Abstract
We conclude that Par2 activation in the immune system aggravates hepatitis and that Par2 activation in the damaged tissue promotes liver regeneration. When we incorporate this finding and revisit the literature reports, we reconciled the conflicts surrounding Par2's role in injury, recovery, and inflammation.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Related Papers
- Lipid-Induced Insulin Resistance Mechanisms: The Link to Inflammation and Type 2 Diabetes.2021 · 2 shared tags
- Dimethyl Fumarate and Intestine: From Main Suspect to Potential Ally against Gut DisordersInternational Journal of Molecular Sciences · 2023 · 2 shared tags
- Gut-Brain Inflammation Due to Toxin-Activated Mast Cells and Microglia in Autism Spectrum DisorderPreprints.org · 2025 · 2 shared tags
- Investigating the effect of a low carbohydrate, high saturated fat diet on concentration levels of markers associated with a leaky gut and the association with glucose homeostasisResearch Square · 2023 · 2 shared tags
- Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune DisordersMolecules · 2025 · 2 shared tags
- The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New PerspectivesAntioxidants · 2023 · 2 shared tags