Development of Chimeric Hepatitis B (HBV) – Norovirus (NoV) P particle as candidate vaccine against Hepatitis B and norovirus infection

Ernawati Arifin Giri-Rachman; Marselina Irasonia Tan; Ashwin Ramesh; Putri Ayu Fajar; Annisa Nurul Ilmi; Debbie Sofie Retnoningrum; Rukman Hertadi; Agustinus Purna Irawan; Gladys Wojciechowska; Lijuan Yuan

doi:10.1016/j.jvacx.2023.100354

Development of Chimeric Hepatitis B (HBV) – Norovirus (NoV) P particle as candidate vaccine against Hepatitis B and norovirus infection

Ernawati Arifin Giri-Rachman, Marselina Irasonia Tan, Ashwin Ramesh +7 more2023Vaccine XJournal Article

10.1016/j.jvacx.2023.100354 PubMed Free full text

GastrointestinalImmune/Innate

Abstract

In summary, the chimeric HBV-HuNoV P particle vaccine given intranasally was safe and induced strong cellular and humoral immune responses in Gn pig. Modifications to the vaccine structure and dosage need to be evaluated in future studies to further enhance immunogenicity and induce more balanced humoral and cellular responses.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady