Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells

N Subramanian; Kaisa Hofwimmer; Beatriz Tavira; Lucas Massier; Daniel P. Andersson; Peter Arner; Jurga Laurencikiene

doi:10.1186/s12933-023-01803-w

Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells

N Subramanian, Kaisa Hofwimmer, Beatriz Tavira +4 more2023Cardiovascular DiabetologyJournal Article

10.1186/s12933-023-01803-w PubMed Free full text

Immune/Innate

Abstract

We suggest that in T2D and CVD, increased production of CCL18 recruits and activates CD4+ T cells to secrete IFN-γ and TGF-β. This, in turn, promotes adipocyte lipolysis - a possible risk factor for cardiometabolic diseases.

Part of CIRS biomarkers research · Curated by Lauren Lowenstein, The Biotoxin Lady

Key Biomarkers

IFN-γTGF-β1