Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
Sean Harrison, Saphira Baumgarten, María Eugenia Chollet +4 more2024Journal of Pediatric Gastroenterology and NutritionJournal Article
Endocrine (ADH/ACTH/MSH)GastrointestinalImmune/Innate
Abstract
Liver organoids could be utilized as a potential screening platform for the development of new, less hepatotoxic PN solutions. Both lipid treatments caused hepatic lipid accumulation, a significant decrease in CYP3A4 activity and a decrease in the RNA levels of both CYP3A4 and CYP1A2 in a dose dependent manner. The presence of high glucose had no additive effect, while Clinoleic at high dose, caused significant upregulation of interleukin 6 and TLR4 expression.
Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady
Key Biomarkers
TLR2/4
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