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CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

Yi Wang, Jiao Liang, Chao Yang +11 more2025CNS Neuroscience & TherapeuticsJournal Article
10.1111/cns.70425PubMedFree full text
Immune/InnateNeurological

Abstract

Our study identified an ECM-associated microglia subtype and explored its interaction with CD8+ T cells, which deepened the understanding of the multifaceted role of microglia in the pathogenesis of CM neuroinflammation.

Key Biomarkers

TNF-α

Symptom Clusters

Neuroinflammation

References (1)

  • TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathwayBrain · 2002

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