Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide

Abstract

In contrast to the strongly allergic lung phenotype induced by fungal spores alone, addition of a relatively high dose of LPS abrogates asthma-like features, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP). These findings extend the already established link between airway mycosis and asthma to HP and describe a robust model for further dissecting the pathophysiology of HP.

Part of Endotoxins research, Mold & water-damaged buildings research · Curated by Lauren Lowenstein, The Biotoxin Lady

Symptom Clusters