Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide
Yuying Zeng, Yun Zhang, Xinyan Huang +8 more2021Respiratory ResearchJournal Article
Respiratory/Sinus
Bacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)
Abstract
In contrast to the strongly allergic lung phenotype induced by fungal spores alone, addition of a relatively high dose of LPS abrogates asthma-like features, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP). These findings extend the already established link between airway mycosis and asthma to HP and describe a robust model for further dissecting the pathophysiology of HP.
Symptom Clusters
Asthma
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