Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance

Abstract

This review elucidates the clinical significance of PNI, summarizes the underlying cellular and molecular mechanisms, introduces various experimental models suitable for studying PNI, and discusses the therapeutic potential of targeting this phenomenon. By delving into the intricate interactions between nerves and tumor cells, we hope this review can provide valuable insights for the future development of CRC treatments.

Part of CIRS Nexus · Curated by Lauren Lowenstein, The Biotoxin Lady