Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential
Abstract
Vasoactive intestinal peptide (VIP) is a basic 28 amino acid peptide that binds to a member of the class II family of G protein-coupled receptors (GPCRs). It is widely expressed throughout the body and plays an important role in numerous biological functions. VIP acts via three different GPCRs: VPAC1, VPAC2, and PAC1, which have been identified in various tissues, including brain, lung, kidney, gastrointestinal tract, tongue, and also on immunocompetent cells such as macrophages and lymphocytes. There is mounting evidence that VIP expression and signaling is altered in numerous neurological disorders, and it is becoming apparent that VIP and its receptors could be therapeutic loci for the treatment of several pathological conditions of the central nervous system. In this review, we describe the pathology of several major neurological disorders and discuss the potential pharmacotherapeutic role of VIP and its receptors for the treatment of disorders such as Alzheimer’s disease, Parkinson’s disease, and Autism Spectrum Disorders.
Cited By (7)
- Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behaviorInternational Journal of Developmental Neuroscience · 2008
- Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistryJournal of Molecular Neuroscience · 2007
- Select cognitive deficits in vasoactive intestinal peptide deficient miceBMC Neuroscience · 2008
- Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular ModelsFrontiers in Neuroscience · 2021
- Potentials of Neuropeptides as Therapeutic Agents for Neurological DiseasesBiomedicines · 2022
- VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studiesCurrent Opinion in Endocrinology Diabetes and Obesity · 2011
- Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders
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