Transforming Growth Factor-β1 Upregulates the Tight Junction and P-glycoprotein of Brain Microvascular Endothelial Cells
Dohgu S, Yamauchi A, Takata F +5 more2004Cellular and Molecular NeurobiologyJournal Article
Neurological
Abstract
1. The present study was aimed at elucidating effects of transforming growth factor-beta (TGF-beta) on blood-brain barrier (BBB) functions with mouse brain capillary endothelial (MBEC4) cells. 2. The permeability coefficients of sodium fluorescein and Evans blue albumin for MBEC4 cells and the cellular accumulation of rhodamine 123 in MBEC4 cells were dose-dependently decreased after a 12-h exposure to TGF-beta1 (0.01-10 ng/mL). 3. The present study demonstrates that TGF-beta lowers the endothelial permeability and enhances the functional activity of P-gp, suggesting that cellular constituents producing TGF-beta in the brain may keep the BBB functioning.
Key Biomarkers
brain microvascular endothelial cellsP-glycoproteinTGF-beta 1Tight Junction Proteins
Cited By (5)
- Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory PainJournal of Cerebral Blood Flow & Metabolism · 2009
- Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β productionBrain Research · 2005
- Structural brain abnormalities in patients with inflammatory illness acquired following exposure to water-damaged buildings: a volumetric MRI study using NeuroQuantNeurotoxicology and Teratology · 2014
- Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrierJournal of Pharmacology and Experimental Therapeutics · 2011
- Inhibition of Transforming Growth Factor-β Production in Brain Pericytes Contributes to Cyclosporin A-Induced Dysfunction of the Blood-Brain BarrierCellular and Molecular Neurobiology · 2007
Related Papers
- Association of mold exposure and solid household fuel use with depression and anxiety among older adults in ChinaEnvironmental Health · 2025 · 1 shared tag
- Pain, Fear, Anxiety, and Stress: Relations to the Endogenous Opioid SystemAdvances in neurobiology · 2024 · 1 shared tag
- Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular ModelsFrontiers in Neuroscience · 2021 · 1 shared tag
- CGRP sensory neurons promote tissue healing via neutrophils and macrophagesNature · 2024 · 1 shared tag
- High Value Phycotoxins From the Dinoflagellate ProrocentrumFrontiers in Marine Science · 2021 · 1 shared tag
- Invited review: Mechanisms of hypophagia during diseaseJournal of Dairy Science · 2021 · 1 shared tag