Control of regulatory T cell lineage commitment and maintenance
Abstract
Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells.
Key Biomarkers
Cited By (8)
- Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cellsNature Immunology · 2013
- Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by Il-4 and STAT6Journal of Leukocyte Biology · 2010
- Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasisImmunity · 2010
- Nature and nurture in Foxp3 (+) regulatory T cell development, stability, and functionHuman Immunology · 2012
- Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspectiveNature reviews. Immunology · 2009
- Developmental plasticity of Foxp3+ regulatory T cellsCurrent Opinion in Immunology · 2010
- Glatiramer acetate for the treatment of multiple sclerosis: evidence for a dual anti-inflammatory and neuroprotective role
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