An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis
Loftus TM1999Seminars in Cell and Developmental BiologyReview
CardiovascularEndocrine (ADH/ACTH/MSH)GastrointestinalHypothalamic-PituitaryImmune/InnateMusculoskeletalNeurologicalOcularRespiratory/Sinus
ActinomycetesBacterial EndotoxinsIndoor Mold (Stachybotrys, Aspergillus, etc.)MycotoxinsVolatile Organic Compounds (VOCs)Water-Damaged Buildings (WDB)
Abstract
Mounting evidence supports a 'lipostatic' model for the regulation of adipose mass. In such a model, signals are generated in the periphery in proportion to adipose mass that act on hypothalamic control centers in the brain to regulate food intake and energy expenditure. Two such signals, leptin and insulin, have been identified and found to dramatically lower food intake and body weight. Several signalling molecules in the effector pathways that mediate the response to these signals in the brain have also been identified. The regulation of these factors and the nature of the adipose-CNS regulatory loop will be discussed.
Key Biomarkers
Alpha Melanocyte Stimulating Hormone (MSH)Immunoglobulin E (IgE)LeptinMatrix Metalloproteinase 9 (MMP9)Vascular Endothelial Growth Factor (VEGF)Visual Contrast Sensitivity (VCS)
Symptom Clusters
Endocrine: night sweats, excessive thirst, frequent urinationGastrointestinal: appetite swingsMusculoskeletal: muscle aches, joint pain, ice pick painNeurological: memory loss, concentration difficulty, confusion, word finding difficulty, headache, light sensitivityNeuropsychiatric: mood swings, fatigueRespiratory: cough, shortness of breath, sinus congestionSensory: tingling in extremities
Cited By (2)
- Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanismsNeurotoxicology and Teratology · 2006
- A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildingsNeurotoxicology and Teratology · 2005
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