MRS shows abnormalities before symptoms in familial Alzheimer disease
Alison K. Godbolt, Adam Waldman, David MacManus +5 more2006NeurologyJournal Article
Neurological
Abstract
Metabolic changes are detectable in presymptomatic mutation carriers years before expected onset of Alzheimer disease. Their magnitude is related to proximity of expected age at onset.
Key Biomarkers
MR Spectroscopy metabolic abnormalities
Symptom Clusters
Presymptomatic metabolic changes
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